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Saturday, August 8, 2020 | History

2 edition of controlled release of macromolecules from macroporous hydrophyllic polymer matrices. found in the catalog.

controlled release of macromolecules from macroporous hydrophyllic polymer matrices.

Roisin Lesley McCallon

controlled release of macromolecules from macroporous hydrophyllic polymer matrices.

by Roisin Lesley McCallon

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Published by Aston University. Department of Pharmaceutical Sciences in Birmingham .
Written in English


Edition Notes

Thesis (PhD) - Aston University, 1990.

ID Numbers
Open LibraryOL13907518M

  Uniform microparticle systems for controlled release of small-molecule drugs. Compared to conventional dosage forms, biodegradable polymeric matrices provide enhanced delivery for small-molecule drugs, yet an important limitation of these matrices has been the difficulty of designing systems exhibiting precisely controlled release Cited by: Hydrogels are being investigated recently for the bioactive molecules (in particular pharmaceutical proteins) controlled release, such as matrices, and for the living cells encapsulation.

Nanoporous capsules of block co-polymers of [(MeO-PEG-NH)-b-(L-GluA)]-PCL for the controlled release of anticancer drugs for therapeutic applications Article in Nanotechnology 27(12) interaction with solvents (swelling and drug release), binding of ions to macromolecules, adsorption of macromolecules (stabilizers for suspension and emulsion), formation of a gel layer upon immediate exposure of the hydrophilic polymer or the water-soluble polymer to the aqueous medium, allow the slow release of drug into the bulk medium, rate can be controlled by modifying the polymer.

In swelling-controlled systems the drug is immobilized in a glassy, hydrophilic polymer and is released as a swelling front moves into the matrix. In chemically controlled systems, rate of drug release is controlled Cited by: 3. Controlled-release formulations offer (1) greater efficacy because optimal concentrations of active ingredient can be maintained in the environment of use, (2) improved safety from reliable release .


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Controlled release of macromolecules from macroporous hydrophyllic polymer matrices by Roisin Lesley McCallon Download PDF EPUB FB2

The underlying principle involved photo-polymerisation of the monomer, hydroxyethyl methacrylate, around frozen ice crystals, leading to the production of a macroporous hydrophilic matrix.

Bead form matrices were fabricated in controllable size Cited by: 2. The controlled release of macromolecules from macroporous hydrophilic polymer matrices. Thesis (Thesis) Find all citations by this author (default).

The controlled release of macromolecules from macroporous hydrophilic polymer matrices. By R.L McCallion. Abstract. SIGLEAvailable from British Library Document Supply Centre- Author: R.L McCallion.

The controlled release of macromolecules from macroporous hydrophilic polymer matrices. Author: McCallion, Roisin Lesley. Release of protein from the hydrogel For controlled release of proteins, the samples were prepared by mixing the desired amount of protein into the monomer solution prior to polymerization.

The resulting hydrogel was cut into 13mmxl3mmx mm slabs for release by: Stimuli-responsive capsules are of interest in drug delivery, fragrance release, food preservation, and self-healing materials.

Many methods are used to trigger the release of encapsulated contents. Here we highlight mechanisms for the controlled release Cited by: Journal of Controlled Release(), DOI: /l K.

Papadokostaki. Combined experimental and computer simulation study of the kinetics of solute release from a relaxing swellable polymer matrix. Release Cited by: Magnetic Nanoparticles Create Hot Spots in Polymer Matrix for Controlled Drug Release.

Nanomaterials8 (10), DOI: /nanoCited by: Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release. Chemical Reviews(4), DOI: /v.5bCited by: Drug release from hydrogel matrices v - specific volume of the polymer, V1 - molar volume of water, χ12 - parameter of polymer-water interaction.

The network mesh size is a measure of space. Volume II discusses individual polymers and their industrial syntheses, Volume III the fundamentals of physical structures and properties, and Volume IV the processing and application of polymers as plastics, fibers, elastomers, thickeners, etc.

The world of macromolecules. The analysis of the present work used for assessing whether a swelling-controlled drug release mechanism could or could not operate in the case of compressed hydrophilic matrices made of cellulose ethers Cited by: Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms.

The book primarily discusses classes of polymers 3/5(3). Freeze-thaw polymerization has been used to generate a bead-formed (– μm) macroporous hydrophilic matrix with potential for the sustained release of macromolecules.

While the incorporation of FITC-dextrans marginally increased the equilibrium water content, their in vitro release profiles were characterized by an initial burst followed by a low but sustained release Cited by: Novel fast thermal-responsive poly(N-isopropylacrylamide) hydrogels with functional cyclodextrin interpenetrating polymer networks for controlled drug release.

Journal of Polymer ResearchCited by: Overall, it can be concluded that the novel findings of okra biopolymer percolation threshold in developing hydrophilic matrices for controlled release applications contribute to improve their.

Due to the effects of hydrogen bonds and van der Waals forces, the water molecules formed a solvated shell around the macromolecules, connected by hydrogen bonds, so that the hydrophilic chains of macromolecules were fully solvated while the hydrophobic groups condensed Author: Chao Wang, Chao Wang, Xiaopeng Pei, Xiaopeng Pei, Junling Tan, Tongwu Zhang, Kankan Zhai, Kankan Zha.

Exposing polymers to 20 wt% glutathione resulted in 85% degradation within 1 hour. Dox was efficiently incorporated into the polymer matrix at 16 wt% of the polymer with more than 50% loading efficiency, and the authors demonstrated in vitro release Cited by: Lipids; they are nonpolar molecules, therefore will not mix with water, a polar molecule.

Think, "Like to Like". Hydrophilic matrices are an interesting option when developing an oral controlled-release formulation. The present study focuses on oral controlled-release dosage forms and the application of.

Controlled release drug delivery employs drug-encapsulating devices from which therapeutic agents may be released at controlled rates for long periods of time, ranging from days to months.The potential of polymer cryogels for encapsulation and sustained release of hydrophilic drugs has been investigated [21, 22].

By design, the water-soluble drug verapamil hydrochloride was.¾ Drug dispersed in a glassy, hydrophilic matrix ¾ Swelling in aqueous medium allows drug release glassy polymer matrix H2O swelling provides with dispersed drug mobility for drug release Complex release .